How Does Calocurb Activate GLP-1?Updated 2 months ago

Calocurb’s core ingredient, Amarasate® (a patented New Zealand hops extract), supports healthy appetite control by stimulating your body’s natural production of GLP-1, a key gut hormone. But how does this process work?

The Science: “Bitter Brake” and GLP-1 Release

When you take Calocurb, the Amarasate® extract is delivered to the upper intestine, where it activates special bitter taste receptors (TAS2Rs) on enteroendocrine cells lining the gut. This triggers a “bitter brake” signal, which has been shown in clinical research to:

• Stimulate the release of GLP-1 (Glucagon-Like Peptide-1), a hormone that promotes feelings of fullness and slows stomach emptying
• Support secretion of other appetite-regulating hormones like PYY and CCK
• Reduce subsequent calorie intake by making you feel fuller, sooner

Clinical Evidence

Peer-reviewed human studies—including those published in the American Journal of Clinical Nutrition and Nutrients—have confirmed that Amarasate® supplementation increases GLP-1 levels and reduces energy intake in both men and women.
Learn more in the Plant & Food Research Amarasate® science summary or see this clinical study.

Why GLP-1 Matters

GLP-1 is central to appetite regulation and is the same hormone targeted by leading prescription weight-loss medications. By naturally stimulating your own GLP-1 with Calocurb, you can help manage hunger and support a sustainable approach to eating—without drugs or stimulants.

Want to Know More?

Have questions about Calocurb’s mechanism or the clinical research? Contact our support team for details or further reading.