How Does Amarasate Work?Updated 2 months ago

Amarasate®, the active ingredient in Calocurb, is a patented extract from New Zealand hops designed to support healthy appetite control. It works by harnessing a natural mechanism called the “bitter brake”—a gut-brain signaling process that helps you feel full and satisfied sooner.

The Science: Activating Bitter Taste Receptors

When you take Amarasate®, its unique blend of bitter acids travels to your upper intestine, where it activates specialized bitter taste receptors (TAS2Rs) found on enteroendocrine cells in the gut lining. This triggers the release of important satiety hormones:

• GLP-1 (Glucagon-Like Peptide-1): Helps signal fullness and slows gastric emptying, reducing appetite.
• PYY (Peptide YY) and CCK (Cholecystokinin): Further promote satiety and help regulate food intake.

This hormonal response is known as the “bitter brake” effect, helping naturally manage hunger and calorie intake—without stimulants or artificial additives.

Clinically Studied Effects

Human clinical trials have shown that Amarasate® supplementation increases GLP-1, reduces hunger, and lowers calorie intake in both men and women. To read more, see the key published clinical study and the Plant & Food Research summary.

Natural, Safe, and Transparent

Amarasate® is GRAS (Generally Recognized As Safe) certified, vegan-friendly, and non-GMO. It is used in Calocurb as part of a clean-label, quality-tested supplement.

Questions?

To learn more about how Amarasate® works in Calocurb, or for real user experiences, visit our testimonials page or contact support.