Does Calocurb Lose Effectiveness Over Time?

No, current research and user feedback do not indicate that your body builds a tolerance to Calocurb. Its effectiveness does not diminish with continued use over time.

How Calocurb Works

Calocurb’s active ingredient, Amarasate®, is a patented bitter hops extract that stimulates the body’s natural satiety signals via the gut-brain axis. It does this by promoting the release of GLP-1 and other appetite-regulating hormones.

According to a 2024 clinical study in the American Journal of Clinical Nutrition, Amarasate® significantly increases GLP-1 levels without any observed tolerance effects even after several weeks of continuous use (source).

No Known Tolerance Buildup

• Unlike stimulants or caffeine-based products, Calocurb does not rely on central nervous system stimulation.
• Its mechanism is based on naturally occurring physiological responses, making long-term tolerance unlikely.
• Many users report consistent results for months without needing to increase dosage.

Maximizing Long-Term Effectiveness

While Calocurb maintains its biological effect over time, combining it with mindful eating and healthy lifestyle habits enhances outcomes. A few suggestions:

• Take Calocurb 60 minutes before your meal for optimal GLP-1 stimulation.
• Stay hydrated and maintain regular mealtimes.
• Pair with high-fiber, whole-food meals to support digestion and hormone balance.

If you notice any shift in how Calocurb affects your appetite, consider journaling meals and discussing with a nutrition coach or our support team.