Taking two Calocurb capsules can amplify appetite control by increasing GLP-1 stimulation, helping reduce calorie intake and manage cravings more effectively.

<article><p>Calocurb&#x2019;s natural appetite suppressant is powered by Amarasate&#xAE;, which stimulates GLP-1 and other satiety hormones that help curb hunger, reduce cravings and caloric intake. While starting with one capsule is ideal to let your body adjust, many users experience greater appetite control when taking two.</p><p>Taking two capsules increases the dosage of Amarasate&#xAE;, which can intensify the hunger-reducing effects. Clinical trials have shown that Amarasate&#xAE; can reduce calorie intake by up to 18% in the hour following consumption. For many, two capsules provide a more noticeable impact on portion control and snacking habits.</p><p>It&#x2019;s best to follow Calocurb&#x2019;s dosing guidelines: start with one capsule and gradually increase to two per dose if needed. Always take Calocurb on an empty stomach, about an hour before eating, for optimal absorption and effect.</p><p>To learn more, visit our <a href="https://www.calocurb.com/pages/science" target="_blank" rel="noopener noreferrer">Science</a> page, or explore the <a href="https://www.calocurb.com/products/calocurb-glp-1-activator" target="_blank" rel="noopener noreferrer">GLP-1 Activator</a>.</p></article>

Why Take Two Calocurb Capsules?

Learn how to take Calocurb safely and effectively. Discover the best timing, dosage, and tips to get the most out of your appetite support routine.

<article><p>Taking Calocurb correctly can make a big difference in your results. Calocurb is designed to naturally reduce appetite and support mindful eating through Amarasate&#xAE;, a hops-derived extract that activates fullness signals in the gut.</p><h2 id="recommended-dosage">Recommended Dosage</h2><ul><li><strong>Start with one capsule:</strong> Take 1 capsule, 60 minutes before a main meal. Continue this for 2-3 days.&#xA0;</li><li><strong>Increase gradually:</strong> If well tolerated, you may increase to 2 capsules before lunch and 2 before dinner.</li><li><strong>Maximum dose:</strong> Do not exceed 4 capsules per day.</li></ul><h2 id="timing-and-tips">Timing and Tips</h2><ul><li>Take Calocurb with a light snack to reduce any digestive discomfort.</li><li>Drink a full glass of water with each dose.</li></ul><h2 id="when-will-i-feel-it-working">When Will I Feel It Working?</h2><p>Most users begin to notice a reduction in appetite or snacking urges within an hour, or up to a few days (depending on your dosage). For best results, pair Calocurb with balanced meals and healthy lifestyle habits.</p><p>To get the most from your Calocurb experience, check out our <a href="https://www.calocurb.com/pages/science" target="_blank" rel="noopener noreferrer">How It Works</a> page and explore our <a href="https://www.calocurb.com/products/calocurb-glp-1-activator" target="_blank" rel="noopener noreferrer">GLP-1 support product</a> for more information.</p></article>

How to Take Calocurb for Best Results

Calocurb does not lose effectiveness over time. Its active ingredient, Amarasate®, works naturally to support GLP-1 release without triggering tolerance or requiring dosage increases.

<article><h1 id="does-calocurb-lose-effectiveness-over-time">Does Calocurb Lose Effectiveness Over Time?</h1><p>No, current research and user feedback do not indicate that your body builds a tolerance to Calocurb. Its effectiveness does not diminish with continued use over time.</p><h2 id="how-calocurb-works">How Calocurb Works</h2><p>Calocurb&#x2019;s active ingredient, <a href="https://www.plantandfood.com/en-nz/article/the-science-of-amarasate" target="_blank" rel="noopener noreferrer">Amarasate&#xAE;</a>, is a patented bitter hops extract that stimulates the body&#x2019;s natural satiety signals via the gut-brain axis. It does this by promoting the release of GLP-1 and other appetite-regulating hormones.</p><p>According to a 2024 clinical study in the <em>American Journal of Clinical Nutrition</em>, Amarasate&#xAE; significantly increases GLP-1 levels without any observed tolerance effects even after several weeks of continuous use (<a href="https://www.sciencedirect.com/science/article/pii/S2667368124000196" target="_blank" rel="noopener noreferrer">source</a>).</p><h2 id="no-known-tolerance-buildup">No Known Tolerance Buildup</h2><ul><li>Unlike stimulants or caffeine-based products, Calocurb does not rely on central nervous system stimulation.</li><li>Its mechanism is based on naturally occurring physiological responses, making long-term tolerance unlikely.</li><li>Many users report consistent results for months without needing to increase dosage.</li></ul><h2 id="maximizing-long-term-effectiveness">Maximizing Long-Term Effectiveness</h2><p>While Calocurb maintains its biological effect over time, combining it with mindful eating and healthy lifestyle habits enhances outcomes. A few suggestions:</p><ul><li>Take Calocurb 60 minutes before your meal for optimal GLP-1 stimulation.</li><li>Stay hydrated and maintain regular mealtimes.</li><li>Pair with high-fiber, whole-food meals to support digestion and hormone balance.</li></ul><p>If you notice any shift in how Calocurb affects your appetite, consider journaling meals and discussing with a nutrition coach or our <a href="https://www.calocurb.com/pages/contact-us" target="_blank" rel="noopener noreferrer">support team</a>.</p></article>

Does Calocurb Lose Effectiveness Over Time?

Calocurb is non-addictive and safe to stop at any time. You won’t experience withdrawal, and your appetite simply returns to normal levels. No dependency, no side effects.

<article><p>Stopping Calocurb is simple and safe. There are no withdrawal symptoms, no dependency risk, and no addictive ingredients involved. You can stop using Calocurb at any time without adverse effects.</p><h2 id="calocurb-is-non-habit-forming">Calocurb Is Non-Habit Forming</h2><p>Calocurb contains <a href="https://www.plantandfood.com/en-nz/article/the-science-of-amarasate" target="_blank">Amarasate&#xAE;</a>, a hops extract that supports appetite regulation through natural gut hormones like GLP-1. It&#x2019;s not a stimulant, doesn&#x2019;t affect brain chemistry, and has <strong>no addictive properties</strong>.</p><ul><li>No caffeine, sugar, or central nervous system stimulants</li><li>GRAS-certified (Generally Recognized As Safe) by the FDA &#x2014; <a href="https://www.fda.gov/food/food-ingredients-packaging/generally-recognized-safe-gras" target="_blank" rel="noopener noreferrer">learn more</a></li><li>Glyphosate Residue Free certified by The Detox Project</li></ul><h2 id="what-to-expect-when-you-stop">What to Expect When You Stop</h2><p>If you stop taking Calocurb:</p><ul><li>Your natural hunger cues will return to baseline levels</li><li>You may notice an increase in appetite compared to when using Calocurb</li><li>There is no &#x201C;crash&#x201D; or rebound overeating effect, unlike some diet pills or appetite suppressants</li></ul><h2 id="safe-to-restart-anytime">Safe to Restart Anytime</h2><p>You can restart Calocurb whenever you want to support appetite management. Many users take it during high-stress periods, seasonal transitions, or as part of a longer wellness plan.</p><p>If you&#x2019;re stopping your use of Calocurb, we recommend staying hydrated, eating fiber-rich meals, and staying mindful of hunger cues. For tailored support, reach out to our <a href="https://www.calocurb.com/pages/contact-us" target="_blank" rel="noopener noreferrer">customer care team</a>.</p><h2 id="learn-more">Learn More</h2><p>Read more on how Calocurb supports GLP-1 levels in our <a href="https://www.calocurb.com/blogs/all/decoding-glp-1-and-amarasate-what-you-should-know" target="_blank" rel="noopener noreferrer">GLP-1 blog article</a>.</p></article>

What Happens If You Stop Taking Calocurb?

Amarasate®, the active ingredient in Calocurb, is GRAS certified and clinically studied for safety. Learn how to use Amarasate® daily and who should consult a doctor.

<article><p>Yes, Amarasate&#xAE;, the patented bitter hop extract and key active ingredient in Calocurb, is considered safe for daily use by healthy adults. Calocurb&#x2019;s formulation uses Amarasate&#xAE; in doses consistent with those validated in clinical trials and supported by extensive safety research.</p><h2 id="safety-certifications">Safety Certifications</h2><ul><li><strong>GRAS Certification:</strong> Amarasate&#xAE; is <a href="https://www.fda.gov/food/food-ingredients-packaging/generally-recognized-safe-gras" target="_blank" rel="noopener">GRAS (Generally Recognized As Safe)</a> certified, meaning its safety is recognized by scientific experts and regulatory bodies, including the U.S. FDA.</li><li><strong>Glyphosate Residue Free:</strong> Calocurb&#x2019;s canola oil, used as an excipient for Amarasate&#xAE;, is certified <a href="https://detoxproject.org/certification/glyphosate-residue-free/" target="_blank" rel="noopener">Glyphosate Residue Free</a> by The Detox Project, ensuring no detectable residues and enhanced transparency.</li></ul><h2 id="clinical-evidence">Clinical Evidence</h2><p>Multiple human studies, including clinical trials published in scientific journals, demonstrate the safety and tolerability of Amarasate&#xAE; for regular use. Notable research includes:</p><ul><li><a href="https://www.mdpi.com/2072-6643/11/11/2754" target="_blank" rel="noopener">Nutrients (2019):</a> Found Amarasate&#xAE; was well tolerated in daily doses, with no serious adverse effects and mild, transient digestive symptoms in some participants.</li><li><a href="https://www.sciencedirect.com/science/article/pii/S0002916522002088" target="_blank" rel="noopener">AJCN (2022):</a> Demonstrated Amarasate&#xAE;&#x2019;s safety and effectiveness for appetite control.</li></ul><h2 id="how-to-use-amarasate-safely">How to Use Amarasate&#xAE; Safely</h2><p>Follow the Calocurb dosing guidelines for optimal safety and results:</p><ul><li>Start with 1 capsule daily, gradually building to 2 capsules twice a day.</li><li>Take on an empty stomach, 1&#x2013;2 hours before meals, with a glass of water.&#xA0;</li><li style="text-align: left;">See the full dosing schedule below.<img src="https://attachments.gorgias.help/30BVo7vjPa7rvzmQ/hc/z8QbV2PAOR7ogePy/2025061703-dddd0c5d-faba-4f16-8e39-4324791d1d76-9b03c851-2363-448d-9119-9b94ee9a0f08.png" style="width: 300px;" class="fr-fic fr-dib"></li></ul><h2 id="who-should-not-use-amarasate">Who Should Not Use Amarasate&#xAE;?</h2><p>If you are pregnant, breastfeeding, have a medical condition, or are taking prescription medications, consult your healthcare professional before starting Calocurb.</p></article>

Is Amarasate® Safe for Daily Use?

Yes, Calocurb can be taken with GLP-1 receptor agonists like Ozempic or Wegovy, but consult your doctor. Learn how they interact to support appetite control and weight management.

<article><p>Yes, Calocurb can generally be taken alongside a GLP-1 receptor agonist. However, it&#x2019;s important to consult your healthcare provider before combining supplements with prescription medications.</p><h2 id="understanding-the-interaction">Understanding the Interaction</h2><p>Calocurb works by naturally stimulating the body&apos;s GLP-1 response using its active ingredient, <a href="https://www.plantandfood.com/en-nz/article/the-science-of-amarasate" target="_blank">Amarasate&#xAE;</a>, a bitter hop extract. Clinical research, such as that published in <a href="https://www.mdpi.com/2072-6643/11/11/2754" target="_blank"><em>Nutrients</em></a> and the <a href="https://www.sciencedirect.com/science/article/pii/S2667368124000196" target="_blank"><em>American Journal of Clinical Nutrition</em></a>, has shown that Amarasate&#xAE; activates bitter taste receptors in the gut, enhancing GLP-1 release, supporting appetite control, and improving satiety.</p><p>GLP-1 receptor agonists, are synthetic compounds that mimic the GLP-1 hormone to regulate blood sugar, slow gastric emptying, and suppress appetite. Because both products influence the same hormone pathway, using them together may enhance appetite-suppressing effects, that is why it is important to consult with your healthcare practitioner.&#xA0;</p><h2 id="important-considerations">Important Considerations</h2><ul><li><strong>Start low and go slow:</strong> Begin with a reduced Calocurb dose and monitor how you feel. Follow our dosing guide to ease into your regimen.</li><li><strong>Watch for side effects:</strong> Common GLP-1 agonist side effects like nausea, bloating, or reduced appetite may be amplified. Calocurb is generally well tolerated, but always listen to your body.</li><li><strong>Speak to your doctor:</strong> Especially if you&apos;re managing type 2 diabetes, weight loss, or gastrointestinal conditions, a medical professional can help assess your personal risks and benefits.</li></ul><h2 id="final-word">Final Word</h2><p>Calocurb and GLP-1 receptor agonists can complement each other when used carefully. Together, they may offer a dual approach to appetite and weight management&#x2014;one that blends natural support with clinical intervention. But always check with your healthcare provider before combining therapies.</p><p>To learn more about the science behind Calocurb, visit our <a href="https://www.calocurb.com/pages/how-it-works" target="_blank" rel="noopener noreferrer">How It Works</a> page.</p></article>

Can Calocurb Be Taken with a GLP-1 Receptor Agonist?

Wondering how to take Calocurb for the best results? Start with 1 capsule daily, then build to 2 capsules twice daily before meals. Learn the full step-by-step guide here.

<article><p>To ensure the best results and minimize any digestive sensitivity, Calocurb&apos;s recommended dosing schedule is designed for a gradual introduction. The active ingredient - <strong>Amarasate&#xAE;</strong>, is a clinically proven bitter hops extract that supports appetite control by stimulating natural gut hormones like GLP-1.</p><h2 id="step-by-step-dosing-guide">Step-by-Step Dosing Guide</h2><p>Follow this progressive schedule to find your ideal dose:</p><ul><li><strong>Days 1&#x2013;2:</strong> Take <strong>1 capsule daily</strong> on an empty stomach, ideally 1 hour before a main meal.</li><li><strong>Days 3&#x2013;4:</strong> Increase to <strong>1 capsule twice daily</strong> (morning and midday) before a main meal.</li><li><strong>Day 5 onward:</strong> Standard dose is <strong>2 capsules twice daily</strong>, taken 1 hour before a main meal.</li><li><strong>Maximum daily dose:</strong> Do not exceed <strong>4 capsules per day</strong>.</li></ul><p>For visual clarity, see our dosing chart here:<br><img src="https://cdn.shopify.com/s/files/1/0021/9879/8395/files/dosing-schedule.png" alt="Calocurb Dosing Schedule" class="fr-fic fr-dii"></p><h2 id="important-tips">Important Tips</h2><ul><li>Always take Calocurb on an <strong>empty stomach</strong> for optimal absorption, with a large glass of water.</li><li>Wait <strong>at least 1 hour</strong> before eating after taking the capsules.</li><li>If you experience mild digestive discomfort, reduce to a lower dose and build up more slowly.</li></ul><p>Calocurb is GRAS certified and backed by research including a <a href="https://www.sciencedirect.com/science/article/pii/S0002916522002088" target="_blank" rel="noopener">2022 clinical study</a> showing Amarasate&#xAE;&#x2019;s effects on GLP-1 and appetite regulation.&#xA0;</p><p>To hear what others have to say, visit our <a href="https://www.calocurb.co.nz/pages/testimonials" target="_blank">customer testimonials</a> page or explore our <a href="https://www.calocurb.co.nz/blogs/news" target="_blank">wellness blog</a>.</p></article>

Using Calocurb